Publications by authors named "C L'Hostis"
Article Synopsis
- Venesection, a treatment for haemochromatosis, is often prescribed incorrectly, especially in patients with moderate iron accumulation and elevated serum ferritin linked to obesity and metabolic issues.
- In a study of 1,059 French patients from 2012-2015, only 24.4% had the genetic mutation typically associated with haemochromatosis, while a majority had conditions like central obesity or metabolic syndrome.
- The findings suggest that haemochromatosis is often over-diagnosed, and venesection may be misapplied in non-haemochromatosis patients, highlighting the need for reevaluation of treatment guidelines based on true iron overload profiles.
Significant advances in the management of cystic fibrosis (CF) in recentdecades have dramatically changed the epidemiology and prognosis of this serious disease, which is no longer an exclusively pediatric disease. This paper aims to review the changes in the incidence and survival of CF and to assess the impact of the discovery of the responsible gene (the gene) on these changes. The incidence of CF appears to be decreasing in most countries andpatient survival, which can be monitored by various indicators, has improved substantially, with an of approximately50 years today.
View Article and Find Full Text PDFBackground: HFE hemochromatosis is an inborn error of iron metabolism linked to a defect in the regulation of hepcidin synthesis. This autosomal recessive disease typically manifests later in women than men. Although it is commonly stated that pregnancy is, with menses, one of the factors that offsets iron accumulation in women, no epidemiological study has yet supported this hypothesis.
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