Optimizing immunogenicity and product presentation of a SARS-CoV-2 subunit vaccine composition: effects of delivery route, heterologous regimens with self-amplifying RNA vaccines, and lyophilization.

Introduction: Dozens of vaccines have been approved or authorized internationally in response to the ongoing SARS-CoV-2 pandemic, covering a range of modalities and routes of delivery. For example, mucosal delivery of vaccines via the intranasal (i.n.

Comparing Human Performance on Target Localization in Near Infrared and Long Wave Infrared for Cluttered Environments.

In the context of rapid advancements in AI, the accuracies and speeds among various AI models and methods are often compared. However, a basic question is rarely asked: is AI better than humans, and if so, under what conditions? This paper investigates human ability to detect distant landmark targets under cluttered surroundings such as buildings, trees, and clouds in NIR and LWIR images, aiming to facilitate AI object detection performance analysis. Our investigation employs perception tests and a human performance model to analyze object detection capabilities.

Hybrid meta/refractive lens design with an inverse design using physical optics.

Hybrid lenses are created by combining metasurface optics with refractive optics, where refractive elements contribute optical power, while metasurfaces correct optical aberrations. We present an algorithm for optimizing metasurface nanostructures within a hybrid lens, allowing flexible interleaving of metasurface and refractive optics in the optical train. To efficiently optimize metasurface nanostructures, we develop a scalar field, ray-wave hybrid propagation method.

Detection and Localization of Small Moving Objects in the Presence of Sensor and Platform Movement.

In this paper, we address the challenge of detecting small moving targets in dynamic environments characterized by the concurrent movement of both platform and sensor. In such cases, simple image-based frame registration and optical flow analysis cannot be used to detect moving targets. To tackle this, it is necessary to use sensor and platform meta-data in addition to image analysis for temporal and spatial anomaly detection.