Publications by authors named "C Kurts"
Chronic inflammasome activation in mononuclear phagocytes (MNPs) promotes fibrosis in various tissues, including the kidney. The cellular and molecular links between the inflammasome and fibrosis are unclear. To address this question, we fed mice lacking various immunological mediators an adenine-enriched diet, which causes crystal precipitation in renal tubules, crystal-induced inflammasome activation, and renal fibrosis.
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- Healthcare professionals in China are experiencing high levels of anxiety (21%) and depression (21.4%), alongside significant allostatic overload (79.8%), due to a shortage of staff and increased work stress.
- A study involving 9,433 hospital staff assessed various factors including stress, sleep quality (50.4% reported poor sleep), and episodic memory (32.1% had issues), revealing a concerning impact on their mental health and cognitive abilities.
- The study highlights the need for local management and community support to help these workers cope with the intense demands of their roles and improve their overall well-being.
Chemokines guide immune cells during their response against pathogens and tumors. Various techniques exist to determine chemokine production, but none to identify cells that directly sense chemokines in vivo. We have generated CCL3-EASER (ErAse, SEnd, Receive) mice that simultaneously report for Ccl3 transcription and translation, allow identifying Ccl3-sensing cells, and permit inducible deletion of Ccl3-producing cells.
View Article and Find Full Text PDFThree-dimensional (3D) imaging has advanced basic research and clinical medicine. However, limited resolution and imperfections of real-world 3D image material often preclude algorithmic image analysis. Here, we present a methodologic framework for such imaging and analysis for functional and spatial relations in experimental nephritis.
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