Objective: Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone and estradiol might reduce or increase alcohol intake, respectively. However, there is a need for a better understanding of how the menstrual cycle in females and the ratio of progesterone to estradiol in females and males influence alcohol use patterns in individuals with AUD.
View Article and Find Full Text PDFBackground: Lifetime traumatic events are prevalent in women with Premenstrual Dysphoric Disorder (PMDD) and predict stronger premenstrual symptom intensities. Less is known about the unique effects of childhood adversity on PMDD. This study aims to investigate the menstrual cycle related course of mood, stress appraisal and cortisol activity over time and the effects of childhood adversity - by controlling for recent stressful life events - on the cyclicity of these outcomes.
View Article and Find Full Text PDFA cobalt photocatalyst for direct trifluoromethylation of (hetero)arene C(sp)-H bonds is described and shown to operate via visible light activation of a Co-CF intermediate, which functions as a combined chromophore and organometallic reaction center. Chemical oxidations of previously reported (OCO)Co complexes containing a redox-active [OCO] pincer ligand afford a Co-CF complex two oxidation states above Co(II). Computational and spectroscopic studies are consistent with formulation of the product as [(OCO)Co(CF)(THF)(OTf)] () containing an open-shell [OCO] radical ligand bound to a = 0 Co(III) center.
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