Publications by authors named "C Kristiansen"
Aims: In patients with locally advanced non-small cell lung cancer (LA-NSCLC), curative-intent radiotherapy (RT) or chemoradiotherapy (CRT) is associated with considerable toxicity, and approximately half of the patients die within two years. A better understanding of early mortality is needed to improve patient selection and guide supportive interventions. In this population-based, nationwide cohort study, we investigated the incidence, temporal distribution, and risk factors of early mortality.
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- Mitochondrial diseases cause neuronal death and depletion of mitochondrial DNA (mtDNA), with astrocytes potentially playing a damaging role in neurodegeneration.
- Research using induced pluripotent stem cells (iPSCs) from patients with POLG mutations showed that the resulting astrocytes experienced significant mitochondrial dysfunction and developed a toxic phenotype.
- When these dysfunctioning astrocytes interacted with neurons, they induced neuronal death, highlighting a novel toxic contribution of astrocytes to the progression of POLG-related diseases.
Background: Robust optimization has been suggested as an approach to reduce the irradiated volume in lung Stereotactic Body Radiation Therapy (SBRT). We performed a retrospective planning study to investigate the potential benefits over Planning Target Volume (PTV)-based planning.
Material And Methods: Thirty-nine patients had additional plans using robust optimization with 5-mm isocenter shifts of the Gross Tumor Volume (GTV) created in addition to the PTV-based plan used for treatment.
Article Synopsis
- The study aimed to examine if the season during radiotherapy affects the occurrence of grade ≥2 dermatitis in breast cancer patients.
- It involved a retrospective analysis of 327 patients and considered different seasonal periods and treatment factors but found no significant associations.
- The conclusion indicates that the season doesn't affect dermatitis rates, suggesting that it's not a key factor for future clinical trials.
The main purpose of the present study was to investigate the labor market affiliation of NSCLC patients in long-term treatment as well as overall survival and incidence/prevalence. Nationwide retrospective study of all patients with NSCLC in Denmark diagnosed between 2012 and 2018. During the study period NSCLC patients had a median overall survival of 44.
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