Thyrotoxic hypokalemic periodic paralysis induced by high-dose insulin in an adolescent male with type 1 diabetes mellitus.

Introduction: Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare but severe complication of hyperthyroidism characterized by acute muscle weakness. This study reports the first case of THPP in an adolescent with type 1 diabetes mellitus (T1DM) and Graves' disease, triggered by high-dose insulin, high carbohydrate intake, and strenuous exercise. It highlights the clinical presentation, management, and implications of THPP in this context.

Mediation of Epigenetic Mechanisms in the Regenerative Effect of Uridine in a Rat Model of Sciatic Nerve Injury.

Aim: To investigate the possible mediation of epigenetic mechanisms underlying the regenerative effect of uridine in a sciatic nerve transection rat model.

Material And Methods: Fifty adult male rats were randomized to sham, control, and uridine groups. After unilateral transection and primary anastomosis of the right sciatic nerve, a single daily dose of saline (1 ml/kg; sham and control groups) or uridine (500 mg/kg; uridine group) was injected intraperitoneally for a week.

Mono-Palmitoyl-N-Alkylurea Ligands as Specific Activators of Human Toll-Like Receptor 2/6 Heterodimer.

Ligands for Toll-like-receptor 2 (TLR2) have demonstrated significant potential as immune-stimulating components in synthetic vaccines. Activation of TLR2 relies on the formation of dimeric complexes with either TLR1 or TLR6 and the nature of these dimers can impact therapeutic outcomes. The lipopeptide-based TLR2 ligands PamCysSK and PamCysSK have been extensively studied, and their recognition by different TLR-receptor heterodimers, TLR2/TLR1 and TLR2/TLR6, respectively, has been established.

Short-term Uridine Treatment Alleviates Endoplasmic Reticulum Stress via Regulating Inflammation and Oxidative Stress in Lithium-Pilocarpine Model of Status Epilepticus.

Background: Status Epilepticus (SE) leads to the development of epilepsy with the contribution of Endoplasmic Reticulum (ER) stress. Uridine, a pyrimidine nucleoside, has been shown to have neuroprotective and antiepileptogenic effects in animal models. This study aimed to determine whether uridine ameliorates ER stress and apoptosis following epileptogenic insult.

Effect of several nickel-titanium rotary systems on stress distribution in mandibular molars under occlusal forces: a finite element analysis.

This study assessed the stress distribution under occlusal forces in mandibular molars after utilizing several nickel-titanium rotary systems and identified potential root fracture patterns through finite element analysis (FEA). Five three-dimensionally printed mandibular molars were used, with one tooth left unshaped and the remaining four shaped using ProTaper Gold (Dentsply, Tulsa Dental Specialties, Tulsa, OK), Reciproc Blue (VDW, Munich, Germany), XP-endo Shaper (FKG Dentaire, La Chaux-de-Fonds, Switzerland), and Hyflex EDM (Coltene/Whaledent, Altst€atten, Switzerland) rotary systems. Subsequently, micro-CT scans were performed on the teeth, and representative FEA models were generated.