Publications by authors named "C Knuth"
Article Synopsis
- Severe burns lead to a long-lasting hypermetabolic state, suggesting deeper biological processes are at play.
- Research indicates that thermogenic adipose tissues contribute to this hypermetabolism, functioning independently of cold stress.
- Adipose tissue transplantation studies reveal that burn-injured recipients can have their metabolic issues improved by healthy adipose tissue, with potential therapeutic targets identified in immune-adipose interactions via the nicotinic acetylcholine receptor pathway.
Purpose: To describe the clinical characteristics of refugees with HIV from Ukraine that seek continuation of medical care in Germany.
Methods: Fourty-six refugees with HIV that had left Ukraine between 24 February and 30 December 2022 were examined. Information on patients' history was obtained using a standardized questionnaire for clinical care.
Lactate shuttling drives the browning of white adipose tissue after burn.
Am J Physiol Endocrinol Metab
September 2023
High levels of plasma lactate are associated with increased mortality in critically injured patients, including those with severe burns. Although lactate has long been considered a waste product of glycolysis, it was recently revealed that it acts as a potent inducer of white adipose tissue (WAT) browning, a response implicated in mediating postburn cachexia, hepatic steatosis, and sustained hypermetabolism. Despite the clinical presentation of hyperlactatemia and browning in burns, whether these two pathological responses are linked is currently unknown.
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- Propranolol, a beta-blocker, is shown to enhance recovery in severely burned patients by influencing key metabolic processes involved in energy, nucleotide metabolism, and inflammatory responses.
- In a phase II trial with 52 participants, patients receiving propranolol exhibited significant alterations in metabolic and lipid profiles compared to controls, including reduced levels of proinflammatory fatty acids.
- The study concludes that propranolol effectively reduces harmful metabolic stress responses after burn injuries, suggesting a potential therapeutic role in improving patient outcomes.