Publications by authors named "C Knosalla"
Article Synopsis
- Calcification in pulmonary hypertension associated with left heart disease appears to be influenced by the interaction between RUNX2 and TAZ, which are key regulators in osteogenic processes.
- Significant vascular calcification was observed in both patients and rat models, with elevated levels of RUNX2 and TAZ.
- Inhibiting TAZ or RUNX2 effectively reduced vascular calcification and the progression of pulmonary hypertension in the rat model, suggesting potential therapeutic targets.
Article Synopsis
- Scientists wanted to see if a new method called hypothermic oxygenated machine perfusion (HOPE) is better for keeping donor hearts alive before they are transplanted, compared to the traditional cold storage method.
- They did a big study with 229 patients across 15 transplant centers in Europe to compare these two methods.
- The main goal was to find out if using HOPE reduces serious problems after heart transplant surgery, like heart failure or rejection, within the first 30 days.
Heart failure (HF) is a common disease associated with high morbidity and mortality rates despite advanced pharmacological therapies. Heart transplantation remains the gold standard therapy for end-stage heart failure; however, its application is curtailed by the persistent shortage of donor organs. Over the past two decades, mechanical circulatory support, notably Left Ventricular Assist Devices (LVADs), have been established as an option for patients waiting for a donor organ.
View Article and Find Full Text PDFTransplantation of the liver in combination with other organs is an increasingly performed procedure. Over the years, continuous improvement in survival could be realized through careful patient selection and refined organ preservation techniques, in spite of the challenges posed by aging recipients and donors, as well as the increased use of steatotic liver grafts. Herein, we revisit the epidemiology, allocation policies in different transplant zones, indications, and outcomes with regard to simultaneous organ transplants involving the liver, that is combined heart-liver, liver-lung, liver-kidney, and multivisceral transplantation.
View Article and Find Full Text PDFSpeckle-tracking echocardiography (STE) parameters are an integral part of the assessment of left ventricular (LV) function. We aimed to evaluate established and novel STE parameters of LV diastolic function and their prognostic role in patients with LV anteroapical aneurysm undergoing surgical ventricular repair (SVR). We retrospectively examined the data of 137 patients with anteroapical LV aneurysm who underwent SVR.
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