Publications by authors named "C Kloetzer"
Article Synopsis
- Researchers investigated markers that might predict how well patients with relapsed/refractory multiple myeloma respond to CAR T cell therapy, which currently lack clarity.* -
- They found that nonresponders had an immunosuppressive microenvironment with high levels of certain immune cells that hinder CD8 T cell and natural killer cell activity.* -
- The study also revealed that CAR T cells from nonresponders displayed exhausted characteristics, suggesting potential targets like PD1 to enhance therapy effectiveness.*
Background: To date, migraine is diagnosed exclusively based on clinical criteria, but fluid biomarkers are desirable to gain insight into pathophysiological processes and inform clinical management. We investigated the state-dependent profile of fluid biomarkers for neuroaxonal damage and microglial activation as two potentially relevant aspects in human migraine pathophysiology.
Methods: This exploratory study included serum and cerebrospinal fluid (CSF) samples of patients with migraine during the headache phase (ictally) (n = 23), between attacks (interictally) (n = 16), and age/sex-matched controls (n = 19).
Objective: The study aimed to test the reliability of a semi-structured telephone interview for the classification of headache disorders according to the ICHD-3.
Background: Questionnaire-based screening tools are often optimized for single primary headache diagnoses [e.g.