Live births and deaths of neonates born to adolescent mothers: analysis of trends and associations from a population study in a region of a middle-income country.

Background: Adolescent pregnancy is associated with adverse outcomes, and although there has been a global decline in the incidence of teenage pregnancies and neonatal deaths, the absolute number remains significant. This study aimed to evaluate temporal trends in live births and neonatal deaths from adolescent mothers, as well as to identify the effect of adolescent pregnancy on neonatal death.

Methods: This is a population-based study of all live births from mothers residing in Sao Paulo state, Brazil, between 2004 and 2020.

Antimicrobial resistance burden estimates from the bottom-up: research priorities for estimating the impact of antimicrobial resistance in Brazil.

Recent estimates of deaths attributable to bacterial antimicrobial resistance (AMR) highlight the immense public health threat of AMR to healthcare systems, economies, and communities in Latin America. Although global modelling studies generate important statistics to motivate and guide global and national agendas, their complex methodology and aggregation mean that they have a more limited impact at the local scales where AMR is experienced and tackled. At the same time, it is increasingly recognised that we need to study and design AMR policies 'from the bottom-up', drawing on data and perspectives that ensure local ownership of the research and policy agenda.

Neonatal mortality of live births with congenital diaphragmatic hernia in São Paulo State, Brazil: Failure of care?

Objective: The aim of this study was to analyze if the healthcare organization of perinatal care and availability of referral neonatal intensive care units (NICU) impacted congenital diaphragmatic hernia (CDH) neonatal mortality in the period 2004-2020. This study analyzed the spatial distribution of neonatal deaths of live births with CDH in São Paulo State, Brazil, and its association with NICU beds' availability.

Methods: Population-based study of all live births in São Paulo State from mothers residing in the same State, from 2004 to 2020.

Space scan statistics to identify clusters of neonatal mortality associated with bacterial sepsis.

Our study aim was to identify high-risk areas of neonatal mortality associated with bacterial sepsis in the state of São Paulo, Southeast Brazil. We used a population-based study applying retrospective spatial scan statistics with data extracted from birth certificates linked to death certificates. All live births from mothers residing in São Paulo State from 2004 to 2020 were included.

Epidemiological trends of isolated and non-isolated central nervous system congenital malformations in live births in a middle-income setting.

Objectives: This study aimed to analyze, in the São Paulo state of Brazil, time trends in prevalence, neonatal mortality, and neonatal lethality of central nervous system congenital malformations (CNS-CM) between 2004 and 2015.

Methods: Population-based study of all live births with gestational age ≥22 weeks and/or birthweight ≥400 g from mothers living in São Paulo State, during 2004-2015. CNS-CM was defined by the presence of International Classification Disease 10th edition codes Q00-Q07 in the death and/or live birth certificates.