Does Low-grade Follicular Lymphoma With a High Proliferation Index Require a Different Treatment Strategy? A Single Center Experience.

Background/aim: Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma worldwide. Patients can have a wide range of clinical features and behavior which does not necessarily correlate to histologic grade or Ki-67 proliferation index. We hypothesized that patients with low grade but high proliferative index (LG/HP) FL have a more aggressive disease course.

Geochemical evolution, geostatistical mapping and machine learning predictive modeling of groundwater fluoride: a case study of western Balochistan, Quetta.

Around 2.6 billion people are at risk of tooth carries and fluorosis worldwide. Quetta is the worst affected district in Balochistan plateau.

A Case of Fulminant Cerebral Edema Leading to Death After Chimeric Antigen Receptor T-Cell Therapy.

Chimeric antigen receptor (CAR) T-cell therapy has transformed treatment of refractory B-cell malignancies; however, treatment puts patients at risk for side effects secondary to the amplified immune response it induces. Fulminant cerebral edema (FCE) is one of the rarest, yet most devastating side effects following CAR T-cell therapy. Due to this rarity, FCE has not been well characterized and the risk factors associated with its development are not fully understood.

Prescription ethics in a low-middle income country: Thematic analysis of research from Pakistan.

The ethics of physician prescriptions is a matter of global concern. While commonalities exist in reasons for unethical prescribing practices such as physician incentivization by pharmaceutical companies, the underlying social determinants may be different across countries and socioeconomic strata. This scoping review has collected themes from publications around prescription ethics from Pakistan.