Publications by authors named "C Keyserling"
Microorganism colonization of peripheral venous catheters in a small animal clinical setting.
J Vet Emerg Crit Care (San Antonio)
November 2023
Objective: To compare the incidence of microorganism colonization of peripheral venous catheters (PVCs) placed in the Emergency Department (ED) to those placed in a routine preoperative setting. The relationship between catheter tip colonization and patient urgency (as assessed by triage priority) was also evaluated.
Design: Prospective, observational study from January 2021 to October 2021.
Article Synopsis
- - This clinical trial assessed the effectiveness of the HDL mimetic CER-001 in patients with very low levels of HDL cholesterol, aiming to see if it could help reduce atherosclerosis as previous trials had not shown results in patients with normal HDL levels.
- - 30 patients with familial hypoalphalipoproteinemia were treated with either CER-001 or a placebo over 24 weeks, with evaluations using advanced imaging techniques to measure changes in artery wall size and inflammation.
- - Results showed no significant difference in vessel wall size or inflammation between the treatment and placebo groups after 24 weeks, indicating that CER-001 did not provide the expected benefits in this specific patient population.
Article Synopsis
- CER-001 is an engineered HDL mimetic showing promise in reducing cholesterol and vascular inflammation, with a previous study indicating potential plaque regression in patients with high coronary plaque burden.
- The objective of the latest study was to assess the effect of CER-001 infusions on coronary atherosclerosis progression in patients already on statins.
- Conducted as a double-blind trial, 272 participants received either CER-001 or placebo over 10 weeks, focusing on changes in atheroma volume and overall safety.
Thoracic radiographs are used as a screening tool for dogs and cats with a variety of disorders that have no clinical signs associated with thoracic structures. However, this practice has never been supported by an evidence-based study. The objective of this retrospective observational study was to determine if certain canine and feline populations have a higher proportion of radiographic abnormalities, and whether any of these abnormalities are associated with patient hospitalization and outcome.
View Article and Find Full Text PDFBackground: CER-001 is an engineered pre-beta high-density lipoprotein (HDL) mimetic, which rapidly mobilizes cholesterol. Infusion of CER-001 3 mg/kg exhibited a potentially favorable effect on plaque burden in the CHI-SQUARE (Can HDL Infusions Significantly Quicken Atherosclerosis Regression) study. Since baseline atheroma burden has been shown as a determinant for the efficacy of HDL infusions, the degree of baseline atheroma burden might influence the effect of CER-001.
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