Publications by authors named "C Kesrouani"
Article Synopsis
- - Eosinophilic fasciitis (EF), also known as Shulman syndrome, is a rare disorder that causes painful swelling and thickening of skin and soft tissues, and can also affect internal organs like the pleura and kidneys.
- - A case report details a 39-year-old patient with unique multifocal skin involvement, discussing symptoms, tissue analysis, possible conditions to consider, treatment options, and the outcomes for the patient.
- - Early diagnosis of EF is essential for effective treatment and improved outcomes, especially when atypical skin lesions are present.
A critical review of RAF inhibitors in BRAF-mutated glioma treatment.
Pharmacogenomics
September 2024
Article Synopsis
- * The review highlights first-generation BRAF inhibitors like Vemurafenib, Dabrafenib, and Encorafenib, and discusses the complications of paradoxical ERK activation that can occur with these treatments.
- * New pan-RAF inhibitors, particularly Tovorafenib, showcase improved effectiveness and the ability to cross the blood-brain barrier while avoiding paradoxical activation, highlighting the need for ongoing research in this area.
Aim: Bone tumors are rare and have an uneven geographic distribution.
Methods: 730 patients diagnosed with bone tumors were included in this retrospective analysis.
Results: With a 64% rate of malignancy, the most common tumors were metastasis (40%) mostly in the axial skeleton, Osteosarcoma (9%) mostly in the femur, Osteochondroma (8%) mostly in the femur, giant cell tumors (7%) mostly in the knee, and Ewing's sarcoma (6%) mostly in the axial skeleton.
Aims: NTRK gene fusions have been described in a wide variety of central nervous system (CNS) and soft tissue tumours, including the provisional tumour type 'spindle cell neoplasm, NTRK-rearranged' (SCN-NTRK), added to the 2020 World Health Organisation Classification of Soft Tissue Tumours. Because of histopathological and molecular overlaps with other soft tissue entities, controversy remains concerning the lineage and terminology of SCN-NTRK.
Methods And Results: This study included 16 mesenchymal tumours displaying kinase gene fusions (NTRK fusions and one MET fusion) initially diagnosed as infantile fibrosarcomas (IFS), SCN-NTRK and adult-type fibrosarcomas from the soft tissue, viscera and CNS.