Publications by authors named "C Kern"
Out-of-Pocket Costs Burden in Marketplace Plans for People With Diabetes.
Health Serv Insights
December 2024
Background: The Affordable Care Act (ACA) aims to expand coverage and increase access to health insurance. Despite the increase of insured individuals, there are a number of concerns about whether coverage and care are affordable. Prior studies document a growing concern with rising premiums and cost-sharing, including deductibles, particularly for those with chronic conditions.
View Article and Find Full Text PDFWe develop a (LV Forest) algorithm for the estimation of latent variable scores with one or more latent variables. LV Forest estimates unbiased latent variable scores based on (CFA) models with ordinal and/or numerical response variables. Through parametric model restrictions paired with a nonparametric tree-based machine learning approach, LV Forest estimates latent variable scores using models that are unbiased with respect to relevant subgroups in the population.
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- The study examines the roles of the hippocampus and prefrontal cortex in learning and cognition, focusing on their molecular development through innovative genomic techniques.
- Researchers used over 53,000 single-nucleus profiles to analyze DNA methylation and chromatin conformation changes, finding that these processes occur at different times during development.
- The findings reveal distinct chromatin interactions in neurons versus glial cells and identify specific genetic variants associated with schizophrenia, highlighting the potential of single-cell multi-omics in understanding brain development and neuropsychiatric disorders.
Biological constraint, evolutionary spandrels and antagonistic pleiotropy.
Ageing Res Rev
November 2024
Maximum lifespan differs greatly between species, indicating that the process of senescence is largely genetically determined. Senescence evolves in part due to antagonistic pleiotropy (AP), where selection favors gene variants that increase fitness earlier in life but promote pathology later. Identifying the biological mechanisms by which AP causes senescence is key to understanding the endogenous causes of aging and its attendant diseases.
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- The study aimed to assess how different dosing regimens of ivermectin affect the survival of malaria vectors (mosquitoes) and their potential to reduce malaria transmission.
- An open-label randomized control trial was conducted in Kenya with 36 participants, comparing a single dose of ivermectin, a 3-day regimen of ivermectin, albendazole, and a control group with no treatment.
- Results indicated that both ivermectin regimens significantly impacted mosquito survival within the first week, but the single dose proved to be more effective over a 10-day period compared to the multi-day regimen.