Publications by authors named "C Kelly-Cirino"
Systematic review and meta-analysis of antigen rapid diagnostic tests to detect Zaire ebolavirus.
Diagn Microbiol Infect Dis
January 2025
Article Synopsis
- * The analysis showed that Ag RDTs had a pooled sensitivity of 82.1% and a specificity of 97.0%, indicating that they are quite effective in identifying patients with EVD.
- * While Ag RDTs can reliably confirm EVD, there is a need for high-sensitivity tests that work well in field conditions and can detect various ebolavirus species.
Efforts to control and eliminate measles and rubella are aided by high-quality surveillance data-supported by laboratory confirmation-to guide decision-making on routine immunization strategies and locations for conducting preventive supplementary immunization activities (SIAs) and outbreak response. Important developments in rapid diagnostic tests (RDTs) for measles and rubella present new opportunities for the global measles and rubella surveillance program to greatly improve the ability to rapidly detect and respond to outbreaks. Here, we review the status of RDTs for measles and rubella Immunoglobulin M (IgM) testing, as well as ongoing questions and challenges regarding the operational use and deployment of RDTs as part of global measles and rubella surveillance.
View Article and Find Full Text PDFIn response to the 2015 Zika virus (ZIKV) epidemic that occurred in Brazil, numerous commercial serological assays have been developed for clinical and research applications. Diagnosis of recent infection in pregnant women remains challenging. Having standardized, comparative studies of ZIKV tests is important for implementing optimal diagnostic testing and disease surveillance.
View Article and Find Full Text PDFArticle Synopsis
- Over 1 million children aged 0 to 14 developed tuberculosis in 2021, leading to over 200,000 fatalities, highlighting the urgent need for improved diagnosis and treatment initiation in this age group alongside preventive therapy for high-risk youth.
- The CaP-TB intervention was implemented across 9 sub-Saharan African countries to enhance case finding, management, and treatment provisions at HIV clinics, aiming to provide practical solutions to address tuberculosis in children.
- The evaluation of the intervention showed a significant increase in treatment initiation rates, with ATT and TPT improvements varying across countries, emphasizing its cost-effectiveness and potential positive health impact.