Publications by authors named "C Keating"

Background: The goal of cystic fibrosis transmembrane conductance regulator (CFTR) modulators is to reach normal CFTR function in people with cystic fibrosis. Vanzacaftor-tezacaftor-deutivacaftor restored CFTR function in vitro and in phase 2 trials in participants aged 18 years and older resulting in improvements in CFTR function, as measured by sweat chloride concentrations and lung function as measured by spirometry. We aimed to evaluate the efficacy and safety of vanzacaftor-tezacaftor-deutivacaftor compared with standard of care elexacaftor-tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years and older.

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  • Thoracic and abdominal aortic aneurysms have different genetic and clinical characteristics, which can be better understood using single-cell RNA sequencing rather than traditional bulk RNA methods that average gene expression across all cells.* -
  • Analysis of single-cell datasets identified three distinct populations of smooth muscle cells (SMCs) in aortic tissues, with a significantly higher proportion of a unique SMC group in TAA compared to AAA.* -
  • Certain genes linked to extracellular matrix organization and insulin-like growth factor transport were found to be upregulated in TAA SMCs, suggesting these may play a role in the development of TAAs; further studies are needed to explore these pathways.*
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  • Previous research indicates that cycling at a higher cadence can enhance post-cycling walking speed, but the exact cadence threshold for meaningful improvements is unclear.
  • A study involving 42 young adults assigned them to three groups that cycled at different cadences—TEN, TWENTY, and THIRTY—before measuring gait velocity through a 10-meter walk test.
  • Results showed that only the THIRTY group, cycling at 30% above their self-selected cadence, experienced a statistically and clinically meaningful improvement in walking speed, suggesting this higher cadence is necessary for significant gains in post-cycling gait velocity.
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Attitudes towards autism vary across countries. Some of this variation could reflect differences in cultural values across countries, or differences in how much people know about autism. Until now, most research on this topic has asked people directly about their attitudes towards interacting with autistic people.

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