Publications by authors named "C Karpinskyj"
Objective: To investigate the association between hysterectomy with conservation of one or both adnexa and ovarian and tubal cancer.
Design: Prospective cohort study.
Setting: Thirteen NHS Trusts in England, Wales and Northern Ireland.
Article Synopsis
- Ovarian cancer remains a serious health issue, particularly for postmenopausal women; the UKCTOCS trial was initiated to evaluate if screening could lower mortality rates associated with the disease.
- The study involved over 202,000 postmenopausal women who were randomly assigned to one of three groups: multimodal screening, transvaginal ultrasound screening, or no screening, and data was collected over a median follow-up period of 16.3 years.
- Results showed that the detection rates of ovarian and tubal cancer were similar across all groups, indicating that neither type of screening significantly impacted the mortality from these cancers.
Article Synopsis
- The study revisits the analysis methods for long-term mortality outcomes in a cancer screening trial, due to advancements in statistical methods and new evidence regarding delayed effects.
- In consultation with experts, three analysis options were considered, with most advocating for a new method that accounts for delayed mortality effects.
- The final decision was to use the Versatile test for better accuracy, highlighting the need for improved consensus on mortality outcome reporting in cancer trials.
Background: There is a trend to increasing use of routinely collected health data to ascertain outcome measures in trials. We report on the completeness and accuracy of national ovarian cancer and death registration in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).
Methods: Of the 202,638 participants, 202,632 were successfully linked and followed through national cancer and death registries of Northern Ireland, Wales and England.
While childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. We performed a pooled analysis among parous participants from 12 case-controls studies comprising 6872 EOC patients and 9101 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression for case-control associations and polytomous logistic regression for histotype-specific associations, all adjusted for potential confounders.
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