Prevention of psychosocial distress consequences in somatic hospital inpatients via a stepped and collaborative care model: protocol of SomPsyNet, a stepped wedge cluster randomised trial.

Introduction: Approximately 30% of somatic hospital inpatients experience psychosocial distress, contributing to increased (re-)hospitalisation rates, treatment resistance, morbidity, and direct and indirect costs. However, such distress often remains unrecognised and unaddressed. We established 'SomPsyNet', a 'stepped and collaborative care model' (SCCM) for somatic hospital inpatients, aiming at alleviating this issue through early identification of distress and provision of appropriate care, providing problem-focused pathways and strengthening collaborative care.

Hydraulic simulation of perforated pipe systems feeding vertical flow constructed wetlands.

For successfully operating a vertical flow constructed wetland, the uniform distribution of wastewater on the surface of the soil filter is essential. In research, however, this aspect is often overlooked. This study presents a methodology for assessing discharge uniformity from perforated pipe systems via hydraulic modeling.

Pharmacokinetics in stable kidney transplant recipients after conversion from twice-daily to once-daily tacrolimus formulations.

Background: A prolonged-release formulation of tacrolimus for once-daily administration (Tacrolimus QD) has been developed to offer potential improvements in patient adherence. This study compared the pharmacokinetics (PK) of tacrolimus in stable kidney transplant recipients before and after conversion from twice-daily tacrolimus (Tacrolimus BID) to Tacrolimus QD.

Methods: This was an open-label, multicenter replicate design study in stable adult kidney transplant recipients (≥6 months posttransplantation) maintained on Tacrolimus BID.

A new sewage exfiltration model--parameters and calibration.

Exfiltration of waste water from sewer systems represents a potential danger for the soil and the aquifer. Common models, which are used to describe the exfiltration process, are based on the law of Darcy, extended by a more or less detailed consideration of the expansion of leaks, the characteristics of the soil and the colmation layer. But, due to the complexity of the exfiltration process, the calibration of these models includes a significant uncertainty.

Groundwater infiltration, surface water inflow and sewerage exfiltration considering hydrodynamic conditions in sewer systems.

Sewer systems are closely interlinked with groundwater and surface water. Due to leaks and regular openings in the sewer system (e.g.