Publications by authors named "C Karlsen"

Article Synopsis
  • Understanding the gut microbiome is crucial for sustainable aquaculture as it affects fish digestion, metabolism, health, and growth.
  • The Salmon Microbial Genome Atlas has compiled 211 high-quality bacterial genomes from wild and farmed Atlantic salmon, revealing diverse taxonomic classifications and new species.
  • The study characterized key bacterial populations that can break down dietary fibers and produce beneficial compounds, providing a valuable resource for future research on salmon nutrition and health.
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Article Synopsis
  • - This study presents the first spatial transcriptomic atlas of Atlantic salmon skin using the Visium Spatial Gene Expression protocol, analyzing samples from four different skin areas of two fish.
  • - High-quality tissue sections were created, resulting in over 80 million reads per sample and the detection of more than 80,000 transcripts and nearly 30,000 genes, with epithelial tissues showing the highest transcript counts.
  • - Key findings include the identification of collagen type 1 as the most abundant gene family, along with specific gene markers for different tissue types, which were validated by a meta-analysis of existing microarray data.
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Focal dark spots (DS) in farmed Atlantic salmon fillets contain a significant number of B cells as revealed by the high abundance of immunoglobulin (Ig) transcripts in transcriptome data. The immune response in DS remains unknown while they represent a major problem in commercial aquaculture. Here, we characterized the diversity and clonal composition of B cells in DS.

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Nephrocalcinosis is a widespread challenge in intensive production of salmon smolt. There is however no consensus on its aetiology, which makes it problematic to implement proper measures to limit its development. We performed a survey of nephrocalcinosis prevalence and environmental factors in 11 different hatcheries in Mid-Norway as well as a 6-month monitoring in one of the hatcheries.

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There is an increased interest in identifying beneficial compounds of plant origin that can be added to animal diets to improve animal performance and have a health-promoting effect. In the present study, nine herb species of the Norwegian wild flora or which can be cultivated in Norway were selected for phytogenic evaluation (hops, maral root, mint, oregano, purslane, rosemary, roseroot, sweet wormwood, yarrow). Dried herbs were sequentially extracted with dichloromethane (DCM), ethanol (EtOH) and finally water (HO) by ultrasound-assisted extraction (UAE).

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