Publications by authors named "C Karki"
Background: Current therapies for complex Crohn's perianal fistulas (CPF) have a limited ability to achieve long-term healing. Darvadstrocel (DVS) is an expanded allogeneic adipose-derived mesenchymal stem cell therapy that has demonstrated efficacy in treating complex CPF in clinical trials. There are, however, limited long-term comparative data with standard of care (SoC).
View Article and Find Full Text PDFBackground: Optimal treatment strategies for seton use in patients with Crohn's perianal fistulas (CPF) remain elusive. This systematic literature review aimed to summarize clinical, patient-reported, and healthcare resource utilization (HCRU) outcomes associated with seton use for symptomatic relief and treatment of complex CPF.
Methods: Electronic databases (MEDLINE, Embase, EBM Reviews, EconLit) were searched.
Article Synopsis
- - The study aimed to create a patient-centered measurement tool to assess the burden of complex cryptoglandular fistulas (CCF) and the effectiveness of treatments, addressing a gap in existing evaluation methods.
- - Researchers conducted a literature review and interviews with colorectal surgeons and patients to gather insights on symptoms and life impacts related to CCF, using this information to develop a conceptual model and draft a CCF-specific patient-reported outcome measure (PROM).
- - The final PROM identifies ten key symptoms and eleven major impacts on patients' lives, including issues like pain, embarrassment, and mood disturbances, which were highlighted as significant by patients during interviews.
Article Synopsis
- Patients with Crohn's disease who also have perianal fistulas face additional complications like fecal incontinence, pain, and a higher treatment burden compared to those without these fistulas.
- A study involved 929 patients across three cohorts to assess their quality of life and treatment preferences using validated questionnaires and a discrete choice experiment.
- Results showed that patients with perianal fistulas experienced worse quality of life scores, and treatment choices were largely influenced by factors such as postoperative discomfort and the rate of fistula healing.
Background: Alpha-1 antitrypsin deficiency is a rare genetic disease and a leading cause of inherited alterations in plasma protein metabolism (APPM).
Aim: To understand the prevalence, burden and progression of liver disease in patients with APPM including alpha-1 antitrypsin deficiency.
Methods: We conducted a retrospective analysis of anonymized patient-level claims data from a German health insurance provider (AOK PLUS).