Publications by authors named "C Kamrath"
To analyze the ecological relationship between COVID-19 incidence in the total population and type 1 diabetes (T1D) incidence in children and adolescents, spatiotemporal models were applied considering time lags from 0 to 12 months. The results do not indicate a positive correlation between COVID-19 incidence and T1D incidence.
View Article and Find Full Text PDF21-Hydroxylase deficiency (21OHD), the most common form of congenital adrenal hyperplasia (CAH), leads to impaired cortisol synthesis and androgen excess. Current treatments of patients with classic 21OHD with supraphysiological doses of glucocorticoids pose risks such as impaired growth and metabolic complications. We discuss the CRH receptor antagonist as a therapeutic option for children with classic 21OHD.
View Article and Find Full Text PDFObjective: This study was conducted to evaluate the effects of early clinical diagnosis of type 1 diabetes by comparison of clinical parameters at diagnosis and during follow-up in patients with pediatric type 1 diabetes with early, intermediate, and late diagnosis.
Research Design And Methods: In a population-based analysis, data on 14,292 pediatric patients with type 1 diabetes diagnosed between 2015 and 2019 were retrieved from the Diabetes Prospective Documentation (DPV) registry in March 2023. Patients were divided into four groups: one with diabetic ketoacidosis (DKA) at diagnosis and three with early, intermediate, or late diagnosis based on age-dependent HbA1c terciles.
Article Synopsis
- This study aimed to analyze trends in the incidence of type 1 and type 2 diabetes in children and adolescents under 20 in North Rhine-Westphalia, Germany, from 2002 to 2022.
- The research utilized registry data, covering a large population, and calculated incidence rates and trends based on age and sex, observing significant increases in diagnoses over the 20-year span.
- Findings revealed that both type 1 and type 2 diabetes incidence rates rose, with a notable peak in 2021, and indicated a wave-like pattern in cases linked to the Covid-19 pandemic.
Objective: Maple syrup urine disease (MSUD), a life-threatening metabolic disorder, is included in newborn screening (NBS) programs worldwide. The study aims to evaluate the impact of NBS on the long-term outcome of MSUD patients.
Methods: We performed a prospective, national, multicenter, observational study.