Publications by authors named "C Kaiser-Farrell"
The mutagenicity of emissions from eight binder systems used in steel foundries.
Am Ind Hyg Assoc J
September 1986
Article Synopsis
- The study assessed the mutagenic activity of emissions generated from pouring molten steel into sand molds made with eight different binder systems, using the Ames Salmonella assay for testing.
- The sampling apparatus involved air filtration through glass fiber filters and impingers filled with ice-cold methanol to capture airborne particles.
- Results indicated that all binder systems produced mutations, with the shell-core system showing the highest mutagenic activity, particularly when an S-9 extract was included, while other systems had varying levels of mutagenic effects.
Article Synopsis
- Workers in ferrous foundries face a heightened risk of lung cancer due to exposure to harmful emissions during the steel casting process.
- Emissions from pouring hot metal into sand molds contain various organic compounds, which have been found to have strong mutagenic effects in laboratory tests.
- Analysis of these emissions revealed that many identified compounds are alkyl derivatives of polycyclic aromatic hydrocarbons, including known carcinogens like benz[a]anthracene and benzo[a]pyrene.
Epidemiological studies suggest an association between excess lung cancer risk and work in ferrous foundries. No causative factors have been identified. The foundry environment is complex, and little is known about the health effects of the levels of known or suspected carcinogens present.
View Article and Find Full Text PDFAn Andersen 2000 sampler was used to collect different size classes of airborne particulate matter in a large steel foundry. When extracts of these particles were assayed for mutagenicity using the Ames Salmonella/S-9 assay, much of the mutagenic activity was found in particles of respirable size. Furthermore, mutagens requiring activation were distributed among the various size classes roughly in proportion to the total surface area of the particles with the smallest class (less than 1.
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