Publications by authors named "C KOHLER"
Background: Surveillance cultures to identify patients colonized with methicillin-resistant Staphylococcus aureus (MRSA) is recommended at pediatric intensive care unit (PICU) admission but doesn't capture other methicillin-resistant Staphylococcus and is resource intensive. We determined the prevalence and identified nasal microbiome predictors for methicillin-resistant Staphylococcus colonization at the time of PICU admission.
Study Design: A prospective cohort study was performed in a 20-bed pediatric intensive care unit (PICU) between 2020-2021.
Background And Hypothesis: Improvements in screening tools for early subthreshold psychosis symptoms are needed to facilitate early identification and intervention efforts, especially given the challenges of rapidly differentiating age-appropriate experiences from potential early signs of emerging psychosis. Tools can be lengthy and time-consuming, impacting their utility and accessibility across clinical settings, and age-normed data are limited. To address this gap, we sought to develop and validate a brief, empirically derived, age-normed, subthreshold psychosis screening tool, for public use.
View Article and Find Full Text PDF: Chronic limb-threatening ischemia (CLTI) is a severe condition with high risks of amputation and mortality, especially in patients with distal crural or pedal artery disease. Despite advances in endovascular techniques, bypass surgery remains crucial for patients with CLTI. This study aimed to investigate amputation-free survival, Wound, Ischemia, and foot Infection (WIfI) staging, and Global Limb Anatomic Staging System (GLASS) classifications in patients undergoing distal crural or pedal bypass for CLTI.
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- Cystoscopy has long been the main method for detecting urothelial carcinoma (UCa), but its invasiveness and costs highlight the need for non-invasive detection methods, leading to the investigation of urinary biomarkers.
- In a study involving 1,119 urine samples, researchers analyzed protein levels of biomarkers CXCL16 and TGFBI, along with DNA methylation at specific CpG sites, to assess their ability to identify UCa compared to other urological and gynecological cancers.
- Results showed that while CXCL16 and TGFBI had moderate sensitivity (31% and 56%) and high specificity (94% and 85%), combining these proteins and methylation markers improved UCa detection sensitivity to 54%
Article Synopsis
- DCD hearts often suffer from ischemia/reperfusion injury due to inflammatory cytokines, which can hurt their contractility, but using cytokine adsorption during blood perfusion could help reduce these cytokines and enhance heart function.
- In the study, porcine DCD hearts were perfused with and without a cytokine adsorber called CytoSorb for 4 hours and then analyzed for heart performance and cytokine levels; those with CytoSorb showed significantly better contractility and lower inflammatory markers.
- Findings indicate that using CytoSorb not only improved heart function at first but also led to beneficial changes in myocardial pathways, suggesting its potential to optimize