Simulation and experiment of leakage and diffusion of natural gas pipelines with different burial depths under different pressures.

In this paper, we studied the diffusion characteristics and distribution patterns of gas leakage in soil from buried natural gas pipelines. The three-dimensional simulation model of buried natural gas pipeline leakage was established using Fluent software. Monitoring points of gas leakage mole fraction were set up at different locations, and the influence of buried depth and pressure factors on the mole fraction and diffusion of leaked gas was analyzed.

Numerical simulation study on the influence of bend diameter rate on the flow characteristics of nature gas hydrate particles.

Bend pipe is a common part of long distance pipeline. There is very important to study the flow law of hydrate particles in the bend pipe, and pipeline design will be optimized. In addition, the efficiency and safety of pipeline gas transmission will be improved.

Observation of non-Hermitian boundary induced hybrid skin-topological effect excited by synthetic complex frequencies.

The hybrid skin-topological effect (HSTE) has recently been proposed as a mechanism where topological edge states collapse into corner states under the influence of the non-Hermitian skin effect (NHSE). However, directly observing this effect is challenging due to the complex frequencies of eigenmodes. In this study, we experimentally observe HSTE corner states using synthetic complex frequency excitations in a transmission line network.

Malate initiates a proton-sensing pathway essential for pH regulation of inflammation.

Metabolites can double as a signaling modality that initiates physiological adaptations. Metabolism, a chemical language encoding biological information, has been recognized as a powerful principle directing inflammatory responses. Cytosolic pH is a regulator of inflammatory response in macrophages.

Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic-ROS Inflammation in Acute Lung Injury.

The sepsis-induced acute lung injury (ALI) still represents one of the leading causes of death in critically ill patients, underscoring the need for novel therapies. Excessive activation of immune cells and damage of reactive oxygen species (ROS) are the main factors that exacerbate lung injury. Here, the multifaceted immunomodulatory nanocomplexes targeting the proinflammatory neutrophilic activation and ROS damage are established.