Publications by authors named "C K Vedolin"
Paradoxical GH increase after oral glucose load in subjects with and without acromegaly.
J Endocrinol Invest
January 2024
Objective: A paradoxical GH rise after the glucose load (GH-Par) is described in about one-third of acromegalic patients. Here, we evaluated the GH profile in subjects with and without acromegaly aiming to refine the definition of GH-Par.
Design: Observational case-control study.
Purpose: The clinical and hormonal overlap between neoplastic (CS) and non-neoplastic (NNH/pCS) hypercortisolism is a challenge. Various dynamic tests have been proposed to allow an early discrimination between these conditions, but to date there is no agreement on which of them should be used.
Aim: To provide an overview of the available tests and to obtain a quantitative synthesis of their diagnostic performance in discriminating NNH/pCS from CS.
Article Synopsis
- The human corticotropin-releasing hormone (hCRH) test is crucial for distinguishing between Cushing disease (CD) and other conditions related to cortisol secretion such as ectopic ACTH secretion (EAS) and pseudo-Cushing syndrome.
- The study involved 200 patients and found that the hCRH test effectively identifies CD from EAS with over 80% sensitivity and specificity by measuring increases in ACTH and cortisol levels.
- Overall, the hCRH test serves as a key diagnostic tool for ACTH-dependent Cushing syndrome and can guide diagnoses in cases of adrenal masses and low ACTH levels.