High-Valent Cobalt-Difluoride in Oxidative Fluorination of Saturated Hydrocarbons.

The heme paradigm where Fe=O acts as the C-H oxidant and Fe-OH rebounds with the formed carbon-centered radical guides the design of the prototypical synthetic hydroxylation catalyst. We are exploring methods to evolve beyond the metal-oxo oxidant and hydroxide rebound, to incorporate a wider array of functional group. We have demonstrated the application of Co(OTf) (10 mol% catalyst; OTf=trimfluoromethanesulfonate) in combination with polydentate N-donor ligands (e.

Calcitriol reduces Newcastle disease virus replication by modulating galectin 3 and pro-inflammatory cytokines.

Calcitriol, or vitamin D (Vit D), is known for promoting strong bones and its ability to modulate inflammation and support the immune system. It has also been reported to be a potent antiviral agent, but the underlying mechanisms behind the mode of action are still unclear. Newcastle disease virus (NDV) belongs to the family Paramyxoviridae and causes infectious diseases in numerous avian species.