AGER-dependent macropinocytosis drives resistance to KRAS-G12D-targeted therapy in advanced pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) driven by the mutation presents a formidable health challenge because of limited treatment options. MRTX1133 is a highly selective and first-in-class KRAS-G12D inhibitor under clinical development. Here, we report that the advanced glycosylation end product-specific receptor (AGER) plays a key role in mediating MRTX1133 resistance in PDAC cells.

Adaptive weighted progressive iterative approximation based on coordinate decomposition.

During the iterative process of the progressive iterative approximation, it is necessary to calculate the difference between the current interpolation curve and the corresponding data points, known as the adjustment vector. To achieve more precise adjustments of control points, this paper decomposes the adjustment vector into its coordinate components and introduces a weight for each component. By dynamically adjusting these weights, we can accelerate the convergence of iterations and enhance approximation accuracy.

Deep Thermalization in Gaussian Continuous-Variable Quantum Systems.

We uncover emergent universality arising in the equilibration dynamics of multimode continuous-variable systems. Specifically, we study the ensemble of pure states supported on a small subsystem of a few modes, generated by Gaussian measurements on the remaining modes of a globally pure bosonic Gaussian state. We find that beginning from highly entangled, complex global states, such as random Gaussian states and product squeezed states coupled via a deep array of linear optical elements, the induced ensemble attains a universal form, independent of the choice of measurement basis: it is composed of unsqueezed coherent states whose displacements are distributed normally and isotropically, with variance depending on only the particle-number density of the system.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.