Publications by authors named "C K Holm"
Treatment for women with postpartum iron deficiency anaemia.
Cochrane Database Syst Rev
December 2024
Rationale: Postpartum iron deficiency anaemia is caused by antenatal iron deficiency or excessive blood loss at delivery and might affect up to 50% of labouring women in low- and middle-income countries. Effective and safe treatment during early motherhood is important for maternal well-being and newborn care. Treatment options include oral iron supplementation, intravenous iron, erythropoietin, and red blood cell transfusion.
View Article and Find Full Text PDFWe study the influence of airborne CO on the charge state of carboxylate stabilized polymer latex particles suspended in aqueous electrolytes. We combine conductometric experiments interpreted in terms of Hessinger's conductivity model with Poisson-Boltzmann cell (PBC) model calculations with charge regulation boundary conditions. Without CO, a minority of the weakly acidic surface groups are dissociated and only a fraction of the total number of counter-ions actually contribute to conductivity.
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- The study investigated the impact of an 8-week preoperative low-load blood flow restricted resistance training (BFR-RT) program on knee osteoarthritis (OA) patients scheduled for total knee arthroplasty (TKA) compared to conventional care with no exercise.
- Results showed no significant differences in physical function or patient-reported outcomes between the BFR-RT and the usual care group at 3 and 12 months post-surgery.
- However, BFR-RT led to notable improvements in lower limb strength at 3 months postoperatively, indicating that it may enhance muscle strength but not necessarily overall physical function post-TKA.
Article Synopsis
- Stimulation of mammalian cells with inflammatory inducers, like lipopolysaccharide (LPS), alters cellular metabolic pathways, particularly affecting enzymes in the tricarboxylic acid (TCA) cycle, which is crucial for releasing pro-inflammatory cytokines.
- The study found that patients with certain genetic variants affecting fatty acid oxidation exhibited inadequate inflammatory responses to LPS due to issues with TLR4 expression and signaling.
- The findings suggest that genes involved in fatty acid metabolism are essential not just for energy production but also for proper immune responses, shedding light on disease mechanisms in conditions like long-chain fatty acid oxidation disorders (lcFAODs).