Publications by authors named "C K Gabel"
Background: Calciphylaxis is a rare and life-threatening condition characterized by cutaneous necrosis resulting from vessel calcification and thrombosis. Commonly associated with end-stage renal disease and hyperparathyroidism, calciphylaxis presents as retiform purpura evolving into necrotic eschars.
Case Report: This report details an atypical case of non-nephrogenic unilateral bullous calciphylaxis in a 71-year-old female, emphasizing the importance of considering calciphylaxis in the differential diagnosis of bullous disorders.
NT-0796 is an ester prodrug which is metabolized by carboxylesterase-1 (CES1) to yield the carboxylic acid NDT-19795, an inhibitor of the NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome. When applied to human monocytes/macrophages which express CES1, however, NT-0796 is much more potent at inhibiting NLRP3 inflammasome activation than is NDT-19795. Comparison of the binding of NDT-19795 and NT-0796 in a cell-based NLRP3 target engagement assay confirms that NDT-19795 is the active species.
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- Patients with calciphylaxis face diagnostic delays, especially those with nonnephrogenic forms and finger lesions, while those with arm and genitalia involvement have shorter delays.
- *The study found that complications per patient have decreased over time, particularly relating to wound infections and hospitalizations.
- *Updated mortality rates show improvements, with one-year mortality at 36.70% for nephrogenic and 30.77% for nonnephrogenic calciphylaxis, underscoring the need for better awareness for early diagnosis.*