Publications by authors named "C K Farmer"
Seventy-two non-lactating, pregnant Angus cows (initial body weight (BW) = 637 ± 13 kg; body condition score (BCS) = 5.5 ± 0.07 yr; and age = 6.
View Article and Find Full Text PDFBackground: Autistic adults are at elevated risk for depression. However, longitudinal data on the trajectory of depressive symptoms and its associated factors in autistic adults are scarce.
Methods: A community sample of 315 autistic adults participated in a two-year longitudinal study from the beginning of (March 2020) to the recovery from the COVID-19 pandemic (March 2022).
Background: Subanesthetic doses of (R,S)-ketamine (ketamine) have demonstrated rapid and robust antidepressant effects in individuals with depression. However, individual variability in response to ketamine exists, and current biomarkers of ketamine treatment response are not entirely understood. Preclinical evidence suggests a link between hypothalamic-pituitary-adrenal (HPA) axis activation, a determinant of the stress response system, and ketamine's efficacy in stressed mice exhibiting enhanced antidepressant responses.
View Article and Find Full Text PDFArticle Synopsis
- The study demonstrated the ability of various crude plant peroxidases, particularly horseradish root (HRP) and pumpkin skin (PKS), to degrade mono- and polyfluorinated phenolic compounds effective for environmental cleanup.
- HRP showed decreased activity with more fluorinated substrates due to steric hindrance, while PKS maintained higher degradation rates, suggesting its larger active site allows for better interaction with these compounds.
- The successful library screening method identified high-activity samples, indicating its potential use for discovering new catalysts for the degradation of other fluorinated compounds in the quest for environmentally friendly biocatalytic solutions.
Objectives: This study examines the impact of slippage in hazard ratios (tending toward the null over subsequent datacuts) for overall survival for combination treatment with a PD-(L)-1 inhibitor and a tyrosine kinase inhibitor in advanced renal cell carcinoma.
Methods: Four trials' Kaplan-Meier curves were digitized over several datacuts and fitted with standard parametric curves. Accuracy and consistency of early data projections were calculated versus observed restricted mean survival time and fitted lifetime survival from the longest follow-up datacut.