Publications by authors named "C K Chng"
Magneto-responsiveness in living organisms, exemplified by migratory birds navigating vast distances, offers inspiration for soft robots and human-computer interfaces. However, achieving both high magneto-responsiveness and resilient mechanical properties in synthetic materials has been challenging. Here, we develop magneto-iono-elastomers (MINEs), combining exceptional magnetization [2.
View Article and Find Full Text PDFManagement of perioperative thyrotoxicosis - what to do when standard therapy is contraindicated or fails?
Front Endocrinol (Lausanne)
December 2024
Background: Current guidelines recommend that hyperthyroid patients should be rendered euthyroid prior to surgical procedures. These guidelines rely heavily on the use of ATDs as the primary medication, and do not give recommendations for patients who have contraindications to ATDs, or for whom standalone ATD treatment is inadequate.
Objectives: To evaluate the efficacy and safety of adjunctive pharmacological therapy and/or therapeutic plasma exchange (TPE) in the perioperative management of patients with thyrotoxicosis who were intolerant to ATD or for whom standalone ATD therapy was inadequate to achieve euthyroidism prior to surgery.
A Rare Case of Functional Metastatic Follicular Thyroid Carcinoma With Concomitant Thyrotoxicosis.
Case Rep Endocrinol
December 2024
We report a case of a 60-year-old lady with metastatic follicular thyroid carcinoma (FTC) who was presented with thyrotoxicosis and heart failure symptoms after total thyroidectomy. Clinical features and investigations led to the diagnosis of functional metastatic FTC with concomitant thyrotoxicosis. Levothyroxine therapy was stopped, and she was treated with propylthiouracil (PTU) followed by serial radioiodine treatments (RAITs) with good control of thyrotoxicosis and metastases.
View Article and Find Full Text PDFArticle Synopsis
- Chromatin phase separation is influenced by factors like post-translational modifications and plays a key role in genomic functions, but the exact mechanisms are still not well understood.
- The study utilized modified solid-state NMR techniques to investigate dynamic components in phosphorylated heterochromatin protein 1α (pHP1α) and found that different NMR methods can provide insights into molecular dynamics within phase-separated systems.
- Results showed that lower KCl concentrations (30 mM) reduced molecular motion in the protein gel, whereas higher concentrations (150 mM) increased motion due to changes in intermolecular electrostatic interactions.
Article Synopsis
- - Difficult tracheal intubation can lead to serious anesthesia-related complications, but current predictive models for identifying difficult airways often lack transparency and trustworthiness in clinical settings.
- - The paper presents G2LCPS, a new semi-supervised method that uses advanced filtering techniques to improve the accuracy of landmark predictions for assessing difficult airways, even with limited labeled data.
- - G2LCPS outperforms existing methods by achieving the lowest normalized mean error in landmark prediction, highlighting its potential to enhance patient safety and clinical outcomes in difficult airway management.