Publications by authors named "C K Brinkmann"
Background: Geographic atrophy (GA) is an advanced form of age-related macular degeneration leading to irreversible vision loss and negative impacts on quality of life.
Methods: To assess the experiences of living with GA, the Geographic Atrophy Insights Survey (GAINS) was conducted between October 12, 2021, and December 10, 2021, captured the responses of individuals ≥60 years with a self-reported GA diagnosis residing in the United States, Canada, Australia, and six European countries. Survey questions focused on the perceptions of individuals living with GA and covered six themes: speed of disease progression, effect on independence, impact on quality of life, emotional toll of GA, misconceptions and need for further education about GA, and clinician interactions.
Article Synopsis
- Many gram-negative pathogenic bacteria, like Xanthomonas campestris pv. vesicatoria (Xcv), utilize type III effector proteins (T3Es) to manipulate host immunity, with XopM being a core T3E whose specific function was previously unknown.
- XopM interacts specifically with vesicle-associated membrane proteins (VAPs) via two FFAT motifs, which are critical for its ability to target plant membranes and potentially disrupt immune responses.
- When introduced into plants, XopM not only supports nonpathogenic bacterial growth but also reduces reactive oxygen species production, indicating its role in suppressing plant immunity during infection.
Aim: To investigate the effects of combined diet-and-exercise interventions in patients with type 2 diabetes mellitus (T2DM).
Data Synthesis: A systematic literature search was conducted on PubMed, Web of Science, SPORTDiscus and BISp Surf databases (latest update in June 2024). A total of 14706 records was identified.
Golden Gate cloning has revolutionized synthetic biology. Its concept of modular, highly characterized libraries of parts that can be combined into higher order assemblies allows engineering principles to be applied to biological systems. The basic parts, typically stored in Level 0 plasmids, are sequence validated by the method of choice and can be combined into higher order assemblies on demand.
View Article and Find Full Text PDFBackground: AURIGA is the largest prospective real-world study to evaluate intravitreal aflibercept (IVT-AFL) treatment of diabetic macular edema (DME) and macular edema secondary to retinal vein occlusion. This article presents 24-month data from the German cohort of treatment-naïve patients with DME.
Methods: Treatment-naïve patients (≥ 18 years) with DME were treated with IVT-AFL at the discretion of the physician in clinical practice.