Publications by authors named "C K Benneh"
Purpose: Major depressive disorder is one of the most common and burdensome psychiatric disorders worldwide. This study evaluated the anxiolytic- and antidepressant-like activity of three semi-synthetic derivatives of xylopic acid (XA) to identify the most promising derivative based on mechanism(s) of action, in vivo pharmacokinetics and in vitro cytotoxicity.
Methods: The anxiolytic potential and the involvement of GABAergic mechanisms were assessed in the elevated plus-maze and open field tests in mice.
Introduction: Preoperative fasting is recommended by international guidelines as a means to minimize the risk of aspiration of gastric content during induction of anesthesia or surgery. Prolonged preoperative fasting is, however, discouraged due to the associated side effects such as dehydration and electrolyte imbalance, which can negatively impact recovery after surgery. An initial quality improvement study revealed poor implementation of the best practice guidelines on preoperative fasting in three departments of a hospital and an institutional action plan was devised to enforce adherence to these guidelines.
View Article and Find Full Text PDFBackground: The Ghana Health Service aims to ensure the health of all Ghanaians. Understanding the factors that influence people's health-seeking behaviour will help the Ghana Health Service evaluate and enact policies that will enable it to achieve set targets. This research aimed to determine the factors that influence the health-seeking behaviour of the residents of Jasikan District and ascertain the importance of the well-being clinic in this context.
View Article and Find Full Text PDFAnalysing data on adverse drug reactions (ADRs) in health facilities is an essential step to help develop effective strategies to reduce their incidence. The objective was to analyse spontaneous ADR reports sent to the Ghanaian Food and Drugs Authority (FDA) by two reporting health facilities over 5 years. Data from duplicate spontaneous ADR reports sent to the FDA (Ghana) from 2014 to 2018 were extracted.
View Article and Find Full Text PDFArticle Synopsis
- Snakebite poses a serious global health threat, especially in rural areas where cases often go unreported due to lack of healthcare access.
- A 6-year study at Jasikan District Hospital in Ghana found that localized pain was the most common symptom, with 74.5% of the 98 cases requiring antivenom treatment.
- Despite issues with antivenom supply, the majority (95%) of patients made full recoveries, indicating that management practices were generally effective, although improvements are needed to align antivenom availability with peak incidence times.