Publications by authors named "C K Arora"

Article Synopsis
  • Tumor cell-derived prostaglandin E2 (PGE2) promotes immunosuppression in the tumor microenvironment by influencing immune cells, but its specific role in tumor cells remains unexplored.
  • Deleting the PGE2 synthesis enzyme or blocking its receptor (EP4) in pancreatic cancer cells activates T cells, changes the immune environment, and inhibits tumor growth.
  • Combining EP4 receptor blockade with immunotherapy leads to complete tumor regressions and enhances immune memory, highlighting the importance of targeting the PGE2 signaling pathway for potential cancer treatments.
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Introduction: Early detection of pancreatic cancer continues to be a challenge due to the difficulty in accurately identifying specific signs or symptoms that might correlate with the onset of pancreatic cancer. Unlike breast or colon or prostate cancer where screening tests are often useful in identifying cancerous development, there are no tests to diagnose pancreatic cancers. As a result, most pancreatic cancers are diagnosed at an advanced stage, where treatment options, whether systemic therapy, radiation, or surgical interventions, offer limited efficacy.

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Objectives: The interpretation of mammograms requires many years of training and experience. Currently, training in mammography, like the rest of diagnostic radiology, is through institutional libraries, books, and experience accumulated over time. We explore whether artificial Intelligence (AI)-generated images can help in simulation education and result in measurable improvement in performance of residents in training.

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The opportunistic use of radiological examinations for disease detection can potentially enable timely management. We assessed if an index created by an AI software to quantify chest radiography (CXR) findings associated with heart failure (HF) could distinguish between patients who would develop HF or not within a year of the examination. Our multicenter retrospective study included patients who underwent CXR without an HF diagnosis.

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 Although abundant literature is currently available on the use of deep learning for breast cancer detection in mammography, the quality of such literature is widely variable.  To evaluate published literature on breast cancer detection in mammography for reproducibility and to ascertain best practices for model design.  The PubMed and Scopus databases were searched to identify records that described the use of deep learning to detect lesions or classify images into cancer or noncancer.

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