Hsp90, DnaK, and ClpB collaborate in protein reactivation.

Hsp70, Hsp90, and ClpB/Hsp100 are molecular chaperones that help regulate proteostasis. Bacterial and yeast Hsp70s and their cochaperones function synergistically with Hsp90s to reactivate inactive and aggregated proteins by a mechanism that requires a direct interaction between Hsp90 and Hsp70 both in vitro and in vivo. and yeast Hsp70s also collaborate in bichaperone systems with ClpB and Hsp104, respectively, to disaggregate and reactivate aggregated proteins and amyloids such as prions.

Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling.

Regulatory T cells (Tregs) with multifaceted functions suppress anti-tumor immunity by signaling surrounding cells. Here we report Tregs use the surface lymphotoxin (LT)α1β2 to preferentially stimulate LT beta receptor (LTβR) nonclassical NFκB signaling on both tumor cells and lymphatic endothelial cells (LECs) to accelerate tumor growth and metastasis. Selectively targeting LTβR nonclassical NFκB pathway inhibits tumor growth and migration in vitro.

Social Vulnerability of Pediatric Populations Living in Ambulance Deserts.

Of the 4.5 million people living in areas of the United States with limited access to ambulance services, approximately 20% are children aged 18 years and younger. Ambulance deserts (ADs) are defined as populated areas in the United States that are not accessible within 25 minutes of where an ambulance is stationed.

Comparative Effectiveness of In-Person and Virtual Picture-Naming Treatment for Poststroke Anomia.

Purpose: In light of COVID-19, telepractice for speech therapy has been increasingly adopted. Telepractice promotes accessibility to therapy services for those in rural environments, lowers the frequency of missed appointments, and reduces the costs of rehabilitation. The efficacy of telepractice has been scarcely explored in the aphasia literature.