Publications by authors named "C Jenkinson"

Marketed endothelin receptor antagonists (ERAs) have been associated with testicular tubular atrophy and decreases in male animal fertility in chronic toxicity studies in rats and dogs. Consistent with these findings, reduced sperm count has been observed in the clinical setting and is considered a potential class risk with chronic administration of ERAs. In contrast, no such effects on male animal fertility are noted with angiotensin II type 1 receptor blocker (ARB) treatment.

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Carbon fiber reinforced polymers (CFRPs, or composites) are increasingly replacing traditional manufacturing materials used in the automobile, aerospace, and energy sectors. With this shift, it is vital to develop end-of-life processes for CFRPs that retain the value of both the carbon fibers and the polymer matrix. Here we demonstrate a strategy to upcycle pre- and postconsumer polystyrene-containing CFRPs, cross-linked with unsaturated polyesters or vinyl esters, to benzoic acid.

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Article Synopsis
  • The study investigates 'digital facilitation' in NHS primary care, aimed at improving patient access and usage of online services in England.
  • It explores various models of digital facilitation, identifying their benefits and challenges, particularly focusing on patients with mental health conditions.
  • The research employs mixed methods, including surveys and interviews, involving a large sample of health staff and patients across four regions, aiming to develop a framework for evaluating these digital interventions.
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The effect of acute exercise on circulating concentrations of vitamin D metabolites is unclear. To address this knowledge gap, we examined the effect of a bout of treadmill-based exercise versus rest on circulating concentrations of 25(OH)D, 25(OH)D, 3-epi-25(OH)D, 24,25(OH)D, 1,25(OH)D, and vitamin D and D in healthy men and women. Thirty-three healthy adults (14 females, 41 (15) years, body mass index 26.

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Fungal secondary metabolite (SM) biosynthetic gene clusters (BGCs) containing dimethylallyltryptophan synthases (DMATSs) produce structurally diverse prenylated indole alkaloids with wide-ranging activities that have vast potential as human therapeutics. To discover new natural products produced by DMATSs, we mined the Department of Energy Joint Genome Institute's MycoCosm database for DMATS-containing BGCs. We found a DMATS BGC in CBS 101889, which also contains a nonribosomal peptide synthetase (NRPS).

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