Publications by authors named "C Jasseron"

Article Synopsis
  • The US heart allocation system prioritizes patients most at risk of death without a transplant, but its current method is flawed and can be manipulated.
  • Researchers aimed to create a new risk score, the US Candidate Risk Score (US-CRS), using clinical data to enhance decision-making for heart transplant candidates.
  • A study involving nearly 17,000 candidates validated the US-CRS, which proved more effective than existing models in predicting mortality rates before transplant.
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Article Synopsis
  • In 2018, France implemented an algorithm-based system for heart transplantation (HT), yet the impact on patients with rare heart failure causes has not been studied until now.!
  • This national study involved adults listed for HT from 2018 to 2020, examining waitlist outcomes and post-transplant results for those with conditions like restrictive cardiomyopathy, hypertrophic cardiomyopathy, and congenital heart disease.!
  • Results showed that while 1604 candidates were listed, outcomes like waitlist death and HT access did not significantly differ among those with rare heart failure causes compared to more common causes, indicating similar risk profiles and access rates.!
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Direct-acting antivirals (DAA) has dramatically improved the prognosis of liver transplantation (LT) candidates for HCV end-stage liver disease (ESLD). We aimed to evaluate the impact of DAA on waiting list (WL) registration and LT activity in France. We evaluated all patients registered to the French WL for HCV ESLD between 2000 and 2018.

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The objective of this study was to investigate the impact of the COVID-19 pandemic on the outcome of patients on the liver transplantation (LT) waitlist in 2020 in France, in particular, the incidence of deaths and delisting for worsening condition, depending on the allocation score component. The 2020 cohort of patients on the waiting list was compared with the 2018/2019 cohorts. 2020 saw fewer LTs than in either 2019 or 2018 (1128, 1356, and 1325, respectively), together with fewer actual brain dead donors (1355, 1729, and 1743).

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The COVID-19 pandemic strongly affected organ procurement and transplantation in France, despite the intense efforts of all participants in this domain. In 2020, the identification and procurement of deceased donors fell by 12% and 21% respectively, compared with the mean of the preceding 2 years. Similarly, the number of new registrations on the national waiting list declined by 12% and the number of transplants by 24%.

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