Publications by authors named "C Jason McKnight"
Background: The international health emergency caused by the emergence of the SARS-CoV-2 virus demonstrated the expanding usefulness of multi-country disease outbreak information gathered through event-based surveillance (EBS) as an extension beyond the main purposes of early warning, alert, and response (EWAR). In this article, previous events of multi-country outbreaks from 2010-2019 were reviewed for how EBS, within an expanded sphere of Epidemic Intelligence (EI), may help to enhance the understanding of outbreaks for a more timely and nuanced, multiple-point trigger approach to health emergencies.
Methods: The public, open-source database of ProMed reports were reviewed for the date of first notification on major outbreaks of infectious diseases and then compared for subsequent dates of any new, exceptional epidemiological findings (novel host, settings, transmission characteristics) as a determining factor for prolonged, multi-country events later acknowledged on the WHO disease outbreak news (DON) website, or by peer-reviewed journal publication if no related DON information became available.
Metastatic castrate-resistant prostate cancer (mCRPC) is a genetically and phenotypically heterogeneous cancer where advancements are needed in biomarker discovery and targeted therapy. A critical and often effective component of treatment includes taxanes. We perform a high-throughput screen across a cohort of 30 diverse patient-derived castrate-resistant prostate cancer (CRPC) organoids to a library of 78 drugs.
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- Clinical trials for cancer treatments should be based on strong scientific understanding and proven drug effectiveness in relevant disease models.
- This study examines the effects of four small-molecule drugs on lymphoma cell lines, revealing that synergistic combinations effectively induce cell death (apoptosis) in a way that mimics actual drug exposure in patients.
- The findings suggest that in vitro drug screening can help identify effective drug combinations that leverage their synergistic effects to tackle the complexity of human cancers, especially in diverse genetic lymphoma models.
Article Synopsis
- The OHC project aims to fill the gaps in Indigenous health data in urban areas by collaborating with local health service providers in six Ontario cities.
- Findings reveal that Indigenous populations face significant undercounting, with census data showing 2-4 times fewer individuals than OHC estimates, along with serious health inequities compared to the general population.
- The study highlights considerable barriers to healthcare, including discrimination and unmet needs, urging immediate changes to health policies and funding to better support Indigenous communities.