Publications by authors named "C Jarvis"
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) is an uncommon hereditary form of rickets characterised by chronic renal phosphate loss and impaired bone mineralisation. This results from compound heterozygous or homozygous pathogenic variants in ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), a key producer of extracellular inorganic pyrophosphate (PPi) and an inhibitor of fibroblast growth factor23 (FGF23). ENPP1 deficiency impacts FGF23 and increases its activity.
View Article and Find Full Text PDFMany adolescents with X-linked hypophosphatemia (XLH) currently have to stop treatment with burosumab at the end of skeletal growth. We describe the experience of a cohort of adolescents with XLH before, during, and after stopping burosumab (median treatment duration 37.5 months).
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- - Vaginitis is a common health issue affecting many women globally, with bacterial vaginosis (BV) being the most frequent type, found in 10-50% of reproductive-aged women.
- - Current diagnostic methods for BV are limited as they typically rely on clinical assessments or the detection of specific microbes, overlooking the complex changes in the vaginal microbiome.
- - A new shotgun metagenomic sequencing test has been developed, demonstrating high sensitivity and specificity for identifying various organisms in the vaginal microbiome, validated across over 7000 samples and certified by several health organizations.
The COVID-19 pandemic led to unprecedented changes in behaviour. To estimate if these persisted, a final round of the CoMix social contact survey was conducted in four countries at a time when all societal restrictions had been lifted for several months. We conducted a survey on a nationally representative sample in the UK, Netherlands (NL), Belgium (BE), and Switzerland (CH).
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- During the early COVID-19 pandemic in Norway, social distancing measures led to a significant reduction in the number of daily social contacts, particularly among younger adults, with a decline of 67-73% compared to pre-pandemic levels.
- *The study involved online surveys of a representative sample of Norwegian adults conducted from April to September 2020, collecting data on nearly 22,000 contacts.
- *Despite relaxations of social distancing over time, the patterns of social interaction remained stable, indicating continued limited contact in community settings versus baseline measurements.*