Publications by authors named "C Janot"
Study Question: Is the 24-h urinary gonadotropin assay an effective diagnostic tool in central precocious puberty (CPP) in girls?
Summary Answer: This study is the first to provide 24-h urinary gonadotropin assay data, using an electrochemiluminescent immunoassay (CMIA), and to report its usefulness as a tool for the diagnosis of CPP.
What Is Known Already: Data about the GnRH test in the diagnosis of CPP are variable and there is no consensus regarding its interpretation. The measurement of FSH and LH in urines was previously reported to be an alternative biological tool.
Article Synopsis
- - Aldosterone synthase deficiency (ASD) is a rare genetic condition causing a lack of aldosterone hormone, primarily seen in newborns and infants, leading to salt wasting, vomiting, and failure to thrive.
- - Early diagnosis is crucial for effective treatment, which includes rehydration and supplementation of salt and fludrocortisone, along with hormone level tests.
- - A case study is presented of a newborn with typical symptoms plus some unusual features, and genetic testing revealed a new variant of the CYP11B2 gene associated with ASD.
Oxetanes are strained heterocycles with unique properties that have triggered significant advances in medicinal chemistry. However, their synthesis still presents significant challenges that limit the use of this class of compounds in practical applications. In this Letter, we present a methodology that introduces a new synthetic disconnection to access oxetanes from native alcohol substrates.
View Article and Find Full Text PDFObjectives: Elevated free T3 (FT3) is an important feature for the early diagnosis of several diseases among which Grave's disease or Allan-Hernon-Dudley syndrome. However, there is a lack of age-adapted reference intervals for plasma thyroid hormones in children. We conducted a study to define reference values of peripheral FT3 in children using a commonly used automated immunoassay.
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