Publications by authors named "C Jalili"
Background And Purpose: Depression is a growing public health concern worldwide, characterized by cognitive impairment and structural abnormalities of the hippocampus. Current antidepressant treatment sometimes causes the late onset of results and the much faster occurrence of side effects. For this reason, the interest in new treatment strategies including exercise and natural products such as curcumin has increased to treat depression.
View Article and Find Full Text PDFHarmine promotes odontoblastic differentiation of dental pulp stem cells.
Nucleosides Nucleotides Nucleic Acids
November 2024
Introduction: Dental pulp stem cells (DPSCs) have the potential to differentiate into various types of tissues including tooth, adipose, cartilage, muscle, nerve, and also possess regenerative properties. Harmine, a beta-carboline alkaloid, has been shown to have antitumor activities and promote bone formation through the differentiation of osteoblasts. The aim of this study was to investigate the effect of harmine on the differentiation of DPSCs into odontoblast cells.
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- Chronic alcohol consumption, particularly from beer, has adverse effects on male fertility, specifically impacting spermatogenesis and the expression of key proteins in testicular tissue.
- In a study with male mice, those consuming alcoholic beer showed increased p21 protein and gene expression, while cyclin D1 levels decreased, alongside signs of oxidative stress and testicular damage over time.
- The findings suggest that alcoholic beer disrupts testicular cell division, leading to decreased sperm production and quality, highlighting the negative effects of ethanol on male reproductive health.
Article Synopsis
- Epilepsy is linked to excessive electrical activity and oxidative stress in neurons, and this study investigates the neuroprotective potential of crocin, a saffron-derived compound, when delivered via solid lipid nanoparticles (SLNC) against PTZ-induced epilepsy in rats.* -
- Rats were treated with SLNC and pure crocin for 28 days, and results showed improved memory and reduced oxidative stress markers (MDA and pro-inflammatory cytokines) with SLNC, indicating its effectiveness compared to pure crocin.* -
- The findings suggest that SLNC enhances antioxidant capacity and neuroprotective factors while lowering inflammatory responses and apoptosis in neurons, highlighting its potential as a promising therapeutic approach for managing seizures.*