Publications by authors named "C Jahansouz"
Background: Over the past 50 years, the incidence of obesity has gradually increased, necessitating investigation into the multifactorial contributors to this disease, including the gut microbiota. Bacteria within the human gut microbiome communicate using a density-dependent process known as quorum sensing (QS), in which autoinducer (AI) molecules (e.g.
View Article and Find Full Text PDFArticle Synopsis
- Pelvic exenterations (PEs) are complex surgeries aimed at treating advanced rectal cancer, with the study focusing on national patterns and outcomes instead of single-center data.* -
- From 673 patients, 76% received neoadjuvant chemotherapy and 24% had positive margins after surgery; younger age and post-surgery chemotherapy improved overall survival, while positive margins worsened prognosis.* -
- The study concluded that a significant portion of patients had positive resections, highlighting the importance of achieving negative margins in surgical procedures for better patient outcomes.*
Laparoscopic colon surgery is performed frequently in the clinical setting for a multitude of reasons including cancer, infection, and autoimmune disease. As a result, extensive research has been conducted in relation to clinical outcomes after surgery, but more recently, in relation to the impact of surgery and other patient factors on physiologic homeostasis including the host microbiome. Despite this, experimental surgical models for laparoscopic colon surgery are scarce in the literature with most studies utilizing rodents.
View Article and Find Full Text PDFBackground And Aims: For patients with obesity and metabolic syndrome, bariatric procedures such as vertical sleeve gastrectomy (VSG) have a clear benefit in ameliorating metabolic dysfunction-associated steatohepatitis (MASH). While the effects of bariatric surgeries have been mainly attributed to nutrient restriction and malabsorption, whether immuno-modulatory mechanisms are involved remains unclear.
Approach And Result: Using murine models, we report that VSG ameliorates MASH progression in a weight loss-independent manner.