Publications by authors named "C Jacoby"
Purpose Of Review: The co-occurrence of diabetes and mental illnesses such as bipolar disorder (BD), obsessive-compulsive disorder (OCD), and schizophrenia creates significant barriers for both people with diabetes (PWD) and their healthcare teams. This literature review provides an analysis of the relationship between diabetes and mental illnesses through exploring epidemiology, shared risk factors, and clinical implications. The aim is to enhance the understanding of these complex comorbidities to guide and improve future research and clinical practice.
View Article and Find Full Text PDFSteroid hormone metabolism by the gut microbiome has multiple implications for mammalian physiology, but the underlying mechanisms and broader significance of this activity remains largely unknown. Here, we isolate a novel human gut bacterium, strain HCS.1, that reduces cortisol, progesterone, testosterone, and related steroid hormones to 3β,5β-tetrahydrosteroid products.
View Article and Find Full Text PDFArticle Synopsis
- Sterols are common compounds found in cell membranes and are resistant to breakdown due to their water-insoluble nature; a new pathway for degrading cholesterol has been discovered in the bacterium Sterolibacterium denitrificans.
- This pathway includes a series of ATP-dependent enzyme reactions that modify sterol structures, specifically targeting cholesterol while being unsuitable for other steroids like stigmasterol.
- Researchers identified a key enzyme from S. denitrificans that facilitates the oxidation of sterol intermediates, ultimately enabling a process to hydroxylate the isoprenoid side chain without requiring oxygen, thus presenting a novel method for sterol degradation.
An organocatalytic [3+2] cycloaddition reaction between thiazolidine-containing β-ketoester 1 and aryl azides 2 was employed to synthesize new 1,2,3-triazolyl-thiazolidine hybrids 3. In this metal-free approach, twelve compounds were isolated in yields ranging from 23 % to 96 % by using diethylamine (10 mol%) and DMSO at 75 °C for 24 hours. DNA-binding assays were conducted through absorption, emission spectroscopy and viscosimetry analysis, to evaluate the interaction capacity of the studied derivatives with nucleic acids.
View Article and Find Full Text PDFBackground Aims: In a previous pilot study of HLA-matched sibling donor hematopoietic cell transplantation (HCT), the authors determined the feasibility of day 4 versus day 5 granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) collection compared with a historical cohort. Given identified differences in the PBSC product (day 4 cohort with significantly lower infused total nucleated, mononuclear and CD3 cells compared with other collection cohorts), the authors performed a follow-up study to determine long-term post-HCT outcomes, including detailed characterization of chronic graft-versus-host disease (GVHD).
Methods: This was a prospective observational study, and the authors collected data on chronic GVHD, staging, sites of involvement and treatments.