Publications by authors named "C J Yuan"
Background: The role of circulating metabolome in cognitive impairment is limited and inconclusive. We aimed to identify plasma metabolites associated with cognitive impairment and evaluate the added predictive capacity of metabolite biomarkers on incident cognitive impairment beyond traditional risk factors.
Method: In the community-based Rugao Longevity and Ageing Study (RuLAS), plasma metabolome was profiled by nuclear magnetic resonance (NMR) spectroscopy.
Background: Tear samples were low-invasive to access and may reflect changes in the brain. We performed an exploratory proteomic analysis using tear samples to identify proteomic signature and potential pathways that may be associated with mild cognitive impairment (MCI) and dementia.
Method: We performed a matched case-control study using tear samples collected from community-dwelling older adults, comprising 13 dementia, as well as 34 MCI and 34 age-, sex-, educational-matched normal cognition (NC) controls (age: 73.
Background: The role of coffee and tea intake in dementia prevention remains inconclusive across studies.
Method: We included 6,001 Health and Retirement Study (HRS) participants (67.5±10.
Background: Dietary factors play a major role in cognitive aging, but few study has compared the associations of major dietary patterns with Alzheimer's disease (AD) mortality and psychometric mild cognitive impairment (p-MCI).
Method: We included 27,773 participants (mean age = 57.0 years, 52.
Background: Dietary factors are modifiable risk factors for dementia. In particular, the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has been associated with better cognitive function and lower risk of dementia. However, circulating metabolomic characteristics of the MIND diet and its associations with cognitive function remains unclear.
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