Publications by authors named "C J Willer"
Article Synopsis
- - The study investigates the role of genetics in postoperative nausea and vomiting (PONV), which impacts patient satisfaction and results in unplanned hospital admissions after surgery, hypothesizing that genetic factors might explain some of the variability in risk that traditional factors do not cover.
- - Researchers conducted a genome-wide association study using data from patients at Michigan Medicine and Vanderbilt University Medical Center, identifying 46 genetic variants associated with PONV and developing a polygenic risk score to better predict occurrences in different patient cohorts.
- - Findings showed that higher polygenic risk scores corresponded with increased risk for developing PONV, suggesting that genetic predisposition combined with known clinical risks can improve understanding and prediction of this complication in surgical patients.
Article Synopsis
- Trace elements play a crucial role in human health but can also be toxic; their absorption and effects are influenced by genetics, but this area is still under-researched.
- This study conducted genome-wide analysis on 57 trace elements using blood samples from Scandinavian individuals, identifying 11 new genetic locations linked to the levels of specific elements such as arsenic, zinc, and selenium.
- The findings suggest some trace elements may have weak to moderate health impacts, with notable indications of increased zinc potentially being harmful and linked to prostate cancer, though more validation is required.
Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness globally, shows disparity in prevalence and manifestations across ancestries. We perform meta-analysis across 15 biobanks (of the Global Biobank Meta-analysis Initiative) (n = 1,487,441: cases = 26,848) and merge with previous multi-ancestry studies, with the combined dataset representing the largest and most diverse POAG study to date (n = 1,478,037: cases = 46,325) and identify 17 novel significant loci, 5 of which were ancestry specific. Gene-enrichment and transcriptome-wide association analyses implicate vascular and cancer genes, a fifth of which are primary ciliary related.
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- Familial hypercholesterolemia (FH) is a genetic condition linked to high LDL cholesterol levels and increased risk of early coronary heart disease (CHD), though its effects on CHD in those with moderate LDL-C levels are not fully understood.
- * This study evaluated the CHD risk from FH variants in individuals with both moderately and severely elevated LDL-C levels and estimated the additional deaths from CHD related to FH in U.S. adults.
- * Among 21,426 participants, those with FH variants had significantly higher rates of developing CHD, with hazard ratios of 2.9 for those with moderately elevated LDL-C and 2.6 for those with severely elevated LDL-C.
Article Synopsis
- A genome-wide association study was conducted on thyroid function, analyzing data from up to 271,040 European individuals, focusing on hormones like TSH, FT4, and T3.
- The study identified 259 significant genetic associations for TSH (61% were novel), and notable findings for FT4 and T3, indicating that specific genes influence thyroid hormone levels and metabolism.
- The research findings enhance the understanding of thyroid hormone roles and suggest that variations in thyroid function may impact various health conditions including cardiovascular issues, autoimmune diseases, and cancer.