Objectives: In order to provide a better insight into the functional capacity of the human gut microbiome, we isolated a novel bacterium, "Candidatus Intestinicoccus colisanans" gen. nov. sp.
View Article and Find Full Text PDFUnderstanding the contributions of mitochondrial genetics to disease pathogenesis is facilitated by a new and unique model-the mitochondrial-nuclear exchange mouse. Here we report the rationale for their development, the methods used to create them, and a brief summary of how MNX mice have been used to understand the contributions of mitochondrial DNA in multiple diseases, focusing on cancer metastasis. Polymorphisms in mtDNA which distinguish mouse strains exert intrinsic and extrinsic effects on metastasis efficiency by altering epigenetic marks in the nuclear genome, changing production of reactive oxygen species, altering the microbiota, and influencing immune responses to cancer cells.
View Article and Find Full Text PDFOcean Alkalinity Enhancement (OAE) is a proposed Negative Emissions Technology (NET) to remove atmospheric CO through the dispersion of alkaline materials (e.g.: calcium hydroxide, slaked lime, SL) into seawater, simultaneously counteracting ocean acidification.
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