Bone scintigraphy and radiology in Paget's disease of bone: a review.

Since effective treatment of Paget's disease is now feasible, knowledge of the possibilities of diagnostic imaging, especially the changes in these images induced by treatment, has become essential. Some forms of treatment may lead to radiographic improvement, indicating that the macroscopic bone texture is changing; radiological imaging, however, is painstaking and liable to technical errors. Different information is derived from the bone scintigram, which is a good monitor of the local bone metabolism and often a sensitive means of identifying lesions.

Relation between signs and symptoms in Paget's disease of bone.

The relation between signs and symptoms of Paget's disease of bone was studied in 180 patients consecutively submitted for treatment. In these patients 826 lesions were identified by scintigraphy. The intensity of scintigraphic uptake was correlated with long-term calcium uptake in bone.