Publications by authors named "C J Teale"
Objectives: To characterize the genetic basis of azithromycin resistance in Escherichia coli and Salmonella collected within the EU harmonized antimicrobial resistance (AMR) surveillance programme in 2014-18 and the Danish AMR surveillance programme in 2016-19.
Methods: WGS data of 1007 E. coli [165 azithromycin resistant (MIC > 16 mg/L)] and 269 Salmonella [29 azithromycin resistant (MIC > 16 mg/L)] were screened for acquired macrolide resistance genes and mutations in rplDV, 23S rRNA and acrB genes using ResFinder v4.
Article Synopsis
- The study aimed to investigate the spread of amikacin-resistant Enterobacteriaceae on a UK pig farm, particularly focusing on Salmonella carrying the rmtB gene.
- Isolates were collected from environmental samples, with real-time PCR and whole-genome sequencing used to analyze the presence of rmtB in both Salmonella and E. coli.
- The findings showed that rmtB was present in multiple strains of Salmonella and E. coli, raising concerns about antibiotic resistance and the importance of ongoing surveillance in agricultural settings.
Article Synopsis
- Livestock-associated MRSA (LA-MRSA) can spread from pigs to workers at abattoirs, posing health risks, so researchers used genomic techniques to investigate this issue.
- Whole genome sequencing (WGS) was conducted on 85 LA-MRSA strains from six abattoirs to determine their genetic relationships and identify shared clones, showing that all strains belonged to a specific lineage (CC398) and were primarily of spa type t011.
- The analysis revealed that transmission likely happens during farm handling, transport, or at abattoirs, indicating that better biosecurity and disinfection practices are needed to protect workers from LA-MRSA contamination.
Recently emerged Infantis strains carrying resistance to several commonly used antimicrobials have been reported from different parts of the globe, causing human cases of salmonellosis and with occurrence reported predominantly in broiler chickens. Here, we performed phylogenetic and genetic clustering analyses to describe the population structure of 417 Infantis originating from multiple European countries and the Americas collected between 1985 and 2019. Of these, 171 were collected from 56 distinct premises located in England and Wales (E/W) between 2009 and 2019, including isolates linked to incursions of multidrug-resistant (MDR) strains from Europe associated with imported poultry meat.
View Article and Find Full Text PDF