S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.

Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as a potential approach for tumor treatment. However, emerging evidence indicates that hepatocellular carcinoma (HCC) cells are generally resistant to ferroptosis and the underlying molecular mechanism is poorly understood. Here, our study confirms that S100 calcium binding protein P (S100P), which is significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ferroptosis.

Myosin light chain 9 mediates graft fibrosis after pediatric liver transplantation through TLR4/MYD88/NF-κB signaling.

Background & Aims: The incidence of graft fibrosis is elevated following pediatric liver transplantation (pLT) and is influenced by cold ischemic time (CIT). Myosin light chain 9 (MYL9), a member of the myosin family, could act on hepatic stellate cells (HSCs) and induce a transition to active phase. We hypothesized that cold ischemic injury could stimulate MYL9 expression and lead to graft fibrosis.

Panel containing three serum microRNAs: a promising biomarker for early detection of bladder cancer.

Background: Bladder cancer (BC) is a common tumor worldwide. Screening for BC currently lacks a highly efficient, non-invasive, and inexpensive method. Serum microRNA (miRNA), which is stable and commonly present, has the potential to serve as a novel marker for BC diagnosis.

Comparative chloroplast genome analysis of five widespread species ( L.) and development of molecular markers for their discrimination.

Background: Zanthoxylum L., an important genus in the Rutaceae family, has great edible and medical values. However, the high degree of morphological similarity among species and the lack of sufficient chloroplast (cp) genomic resources have greatly impeded germplasm identification and phylogenetic analyses of

Methods: Here we assembled cp genomes of five widespread species (, , , and ) in China as a case study, comparative analysis of these assembled cp genomes.

Formation of the rosette-like starch with enhanced V-type crystallization via modified solvent-shifting method.

This research investigated the effect modified solvent-shifting method on the formation, ordered structure, and morphology of V-type starch. Ionic liquid (IL) dissolution and hot ethanol aqueous incubation in gradient concentrations from 30 % to 80 % (v/v) were applied to optimize the relative crystallinity of V-type starch. The results showed that this new method worked in producing V-type conformation, and higher ethanol concentration tended to yield V-type starch with higher crystallinity and more disk-like shape structure within the ethanol range of 30-50 % (v/v).