Publications by authors named "C J Shea"

Acute myocardial infarction (AMI) remains one of the most common causes for cardiogenic shock (CS), with high inpatient mortality (40-50 %). Studies have reported the use of pulmonary artery catheters (PACs) in decompensated heart failure, but contemporary data on their use to guide management of AMI-CS and in different SCAI stages of CS are lacking. We investigated the association of PACs and clinical outcomes in AMI-CS.

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Arsenic (As) is a risk factor for non-melanoma skin cancer (NMSC). From a six-year follow-up study on 7000 adults exposed to As, we reported the associations of single-nucleotide variation in tumor tissue and gene expression. Here, we identify the associations of small deletions (DELs) and transcriptomic profiles in NMSC.

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Background: Preventing sexual assault in the United States (U.S.) military is essential to safeguard the overall well-being of military personnel and support the military to function in alignment with its intended mission and objectives.

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Article Synopsis
  • The traditional neuroimaging research relies on inferential statistics to identify significant effects, but precision medicine demands a predictive modeling approach that enhances generalizability and predictive accuracy.
  • Existing tools for analyzing lesion-behavior often require different software for different data types and problem types, limiting researchers' flexibility and efficiency.
  • A new MATLAB software toolkit has been developed to unify inferential and predictive modeling, supporting various analysis types without restrictions on data modality, and includes features for model optimization and evaluation.
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Background: Academic health centers (AHCs) have traditionally focused on 3 core missions: patient care, research, and education. The current changing health care environment requires AHCs to broaden their focus to improve the health of their communities. This study reports the opportunities and challenges for the 5 North Carolina AHCs addressing social determinants of health (SDOH).

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